Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells.

ABSTRACT:

Background

Exposure to environmental chemicals such as phthalates, phenols, and polycyclic aromatic hydrocarbons (PAHs) during pregnancy can increase the risk of adverse newborn outcomes. We explored the associations between maternal exposure to select environmental chemicals and DNA methylation in cord blood mononuclear cells (CBMC) and placental tissue (maternal and fetal sides) to identify potential mechanisms underlying these associations.

Method

This study included 75 pregnant individuals who planned to give birth at the University of Cincinnati Hospital between 2014 and 2017. Maternal urine samples during the delivery visit were collected and analyzed for 37 biomarkers of phenols (12), phthalates (13), phthalate replacements (4), and PAHs (8). Cord blood and placenta t

SUBMITTER: Puvvula J 

PROVIDER: S-EPMC11217138 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature