Metabolomic profiling of upper GI malignancies in blood and tissue: a systematic review and meta-analysis.

ABSTRACT:

Objective

To conduct a systematic review and meta-analysis of case-control and cohort human studies evaluating metabolite markers identified using high-throughput metabolomics techniques on esophageal cancer (EC), cancer of the gastroesophageal junction (GEJ), and gastric cancer (GC) in blood and tissue.

Background

Upper gastrointestinal cancers (UGC), predominantly EC, GEJ, and GC, are malignant tumour types with high morbidity and mortality rates. Numerous studies have focused on metabolomic profiling of UGC in recent years. In this systematic review and meta-analysis, we have provided a collective summary of previous findings on metabolites and metabolomic profiling associated with EC, GEJ and GC.

Methods

Following the PRISMA procedure, a systematic search of four

SUBMITTER: Balonov I 

PROVIDER: S-EPMC11217139 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature