Association of circulating minerals and vitamins with pregnancy complications: a Mendelian randomization study.

ABSTRACT:

Background

Though considerable studies suggesting connections between micronutrients and pregnancy complications, current evidence remains inconsistent and lacks causative confirmation. Our study aimed to explore the causal links between them with a two-sample Mendelian randomization (MR) analysis.

Methods

Genome-wide association studies (GWAS) data for circulating micronutrients were sourced from GWAS Catalog consortium and PubMed, while data for pregnancy outcomes, including gestational diabetes mellitus (GDM), gestational hypertension (GH), spontaneous abortion (SA), preterm birth (PTB), and stillbirth (SB), were retrieved from the UK Biobank and FinnGen consortia. Causal effects were appraised using inverse variance weighted (IVW), weighted median (WM), and MR-Egger, fol

SUBMITTER: Xie Y 

PROVIDER: S-EPMC11217313 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature