A single-cell sequence analysis of mouse subcutaneous white adipose tissue reveals dynamic changes during weaning.

ABSTRACT: Adipose tissue development begins in the fetal period, and continues to expand after birth. Dysregulation of adipose tissue during weaning may predispose individuals to lifelong metabolic disorders. However, the developmental remodeling of adipose tissue during weaning remains largely unexplored. Here we comprehensively compare the changes in mouse subcutaneous white adipose tissue from 7 days after birth to 7 days after weaning using single-cell RNA sequencing along with other molecular and histologic assays. We characterize the developmental trajectory of preadipocytes and indicate the commitment of preadipocytes with beige potential during weaning. Meanwhile, we find immune cells unique to weaning period, whose expression of extracellular matrix proteins implies potential regulation on

SUBMITTER: Qian S 

PROVIDER: S-EPMC11217364 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature