[¹⁸F]F-AraG imaging reveals association between neuroinflammation and brown- and bone marrow adipose tissue.

ABSTRACT: Brown and brown-like adipose tissues have attracted significant attention for their role in metabolism and therapeutic potential in diabetes and obesity. Despite compelling evidence of an interplay between adipocytes and lymphocytes, the involvement of these tissues in immune responses remains largely unexplored. This study explicates a newfound connection between neuroinflammation and brown- and bone marrow adipose tissue. Leveraging the use of [¹⁸F]F-AraG, a mitochondrial metabolic tracer capable of tracking activated lymphocytes and adipocytes simultaneously, we demonstrate, in models of glioblastoma and multiple sclerosis, the correlation between intracerebral immune infiltration and changes in brown- and bone marrow adipose tissue. Significantly, we show initial evidence th

SUBMITTER: Levi J 

PROVIDER: S-EPMC11217368 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature