Acoustofluidics-enhanced biosensing with simultaneously high sensitivity and speed.

ABSTRACT: Simultaneously achieving high sensitivity and detection speed with traditional solid-state biosensors is usually limited since the target molecules must passively diffuse to the sensor surface before they can be detected. Microfluidic techniques have been applied to shorten the diffusion time by continuously moving molecules through the biosensing regions. However, the binding efficiencies of the biomolecules are still limited by the inherent laminar flow inside microscale channels. In this study, focused traveling surface acoustic waves were directed into an acoustic microfluidic chip, which could continuously enrich the target molecules into a constriction zone for immediate detection of the immune reactions, thus significantly improving the detection sensitivity and speed. To demonstrat

SUBMITTER: Li Y 

PROVIDER: S-EPMC11217392 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature