An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice.

ABSTRACT: Acute immune responses with excess production of cytokines, lipid/chemical mediators, or coagulation factors, often result in lethal damage. In addition, the innate immune system utilizes multiple types of receptors that recognize neurotransmitters as well as pathogen-associated molecular patterns, making immune responses complex and clinically unpredictable. We here report an innate immune and adrenergic link inducing lethal levels of platelet-activating factor. Injecting mice with toll-like receptor (TLR) 4 ligand lipopolysaccharide (LPS), cell wall N-glycans of Candida albicans, and the α₂-adrenergic receptor (α₂-AR) agonist medetomidine induces lethal damage. Knocking out the C-type lectin Dectin-2 prevents the lethal damage. In spleen, large amounts of platelet-a

SUBMITTER: Tanaka S 

PROVIDER: S-EPMC11217416 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature