Time-of-flight resolved stimulated Raman scattering microscopy using counter-propagating ultraslow Bessel light bullets generation.

ABSTRACT: We present a novel time-of-flight resolved Bessel light bullet-enabled stimulated Raman scattering (B²-SRS) microscopy for deeper tissue 3D chemical imaging with high resolution without a need for mechanical z-scanning. To accomplish the tasks, we conceive a unique method to enable optical sectioning by generating the counter-propagating pump and Stokes Bessel light bullets in the sample, in which the group velocities of the Bessel light bullets are made ultraslow (e.g., v_g ≈ 0.1c) and tunable by introducing programmable angular dispersions with a spatial light modulator. We theoretically analyze the working principle of the collinear multicolor Bessel light bullet generations and velocity controls with the relative time-of-flight resolved detection for SRS 3D deep ti

SUBMITTER: Lin S 

PROVIDER: S-EPMC11217417 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature