LC3-associated phagocytosis of neutrophils triggers tumor ferroptotic cell death in glioblastoma.

ABSTRACT: Necrosis in solid tumors is commonly associated with poor prognostic but how these lesions expand remains unclear. Studies have found that neutrophils associate with and contribute to necrosis development in glioblastoma by inducing tumor cell ferroptosis through transferring myeloperoxidase-containing granules. However, the mechanism of neutrophilic granule transfer remains elusive. We performed an unbiased small molecule screen and found that statins inhibit neutrophil-induced tumor cell death by blocking the neutrophilic granule transfer. Further, we identified a novel process wherein neutrophils are engulfed by tumor cells before releasing myeloperoxidase-containing contents into tumor cells. This neutrophil engulfment is initiated by integrin-mediated adhesion, and further mediated by

SUBMITTER: Lu T 

PROVIDER: S-EPMC11217441 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature