Persistent depressive symptoms are associated with frontal regional atrophy in patients with Alzheimer's disease.

ABSTRACT:

Background

Depression in individuals with Alzheimer's disease (AD) is common, difficult to treat and inadequately understood. Previous studies have identified possible differences in regional brain atrophy in individuals with AD and depression, but the results have been inconsistent and some studies had less robust definitions of depression. We aimed to examine regional brain atrophy in two large dementia focused cohorts.

Methods

We used data from Alzheimer's disease neuroimaging initiative (ADNI) and the National Alzheimer's Co-ordinating Center (NACC), for those with data from at least one MRI scan. Depression ratings were available using the Geriatric Depression Scale (GDS) and Neuropsychiatric Inventory (NPI). Intermittent depressive symptoms were defined as one episode

SUBMITTER: Sinclair LI 

PROVIDER: S-EPMC11217758 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature