Galectin-9 as an indicator of functional limitations and radiographic joint damage in patients with rheumatoid arthritis.

ABSTRACT:

Background

Previous studies have revealed that Galectin-9 (Gal-9) acts as an apoptosis modulator in autoimmunity and rheumatic inflammation. In the present study, we investigated the potential role of Gal-9 as a biomarker in patients with rheumatoid arthritis (RA), especially as an indicator of functional limitations and radiographic joint damage.

Methods

A total of 146 patients with RA and 52 age- and sex-matched healthy controls were included in this study. Clinical data including disease activity, physical function, and radiographic joint damage were assessed. Functional limitation was defined as the Stanford Health Assessment Questionnaire (HAQ) disability index >1. Subjects with joint erosion >0 or joint space narrowing >0 were considered to have radiographic joint dama

SUBMITTER: Guo J 

PROVIDER: S-EPMC11217821 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature