Fluorine-18 Prostate-Specific Membrane Antigen-1007 PET/CT vs Multiparametric MRI for Locoregional Staging of Prostate Cancer.

ABSTRACT:

Importance

Prostate-specific membrane antigen (PSMA) demonstrates overexpression in prostate cancer and correlates with tumor aggressiveness. PSMA positron emission tomography (PET) is superior to conventional imaging for the metastatic staging of prostate cancer per current research but studies of second-generation PSMA PET radioligands for locoregional staging are limited.

Objective

To determine the accuracy of fluorine-18 PSMA-1007 PET/computed tomography (18F-PSMA-1007 PET/CT) compared to multiparametric magnetic resonance imaging (MRI) in the primary locoregional staging of intermediate-risk and high-risk prostate cancers.

Design, setting, and participants

The Next Generation Trial was a phase 2 prospective validating paired cohort study assessing the accuracy of

SUBMITTER: Mookerji N 

PROVIDER: S-EPMC11217889 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature