Access to Cyclic Borates by Cu-Catalyzed Borylation of Unactivated Vinylcyclopropanes.

ABSTRACT: We report the copper-catalyzed borylation of unactivated vinylcyclopropanes to form six-membered cyclic borate salts. A copper complex bearing an N-heterocyclic ligand in combination with bis(pinacolato)diboron and LiOtBu catalyzes the ring-opening of the substrate under mild reaction conditions. The protocol can be applied to aryl- and heteroaryl-substituted vinylcyclopropanes and can be conducted on a gram scale. The synthetic utility of the lithium salts of the cyclic borate has been demonstrated through regioselective ring-opening functionalizations.

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11217945 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature