Characterizing reward and relief/habit drinking profiles in a study of naltrexone, varenicline, and placebo.

ABSTRACT:

Introduction

This study aims to clarify differences in mood, craving, and treatment response between reward and relief/habit individuals in a study of naltrexone, varenicline, and placebo. We hypothesized that relief/habit individuals would have a poorer mood during early abstinence and higher levels of alcohol craving than reward individuals. We hypothesized that reward individuals would demonstrate better drinking outcomes on naltrexone versus placebo.

Methods

Data were culled from a randomized, double-blind, placebo-controlled human trial of 53 individuals (18F/16M) with alcohol use disorder randomized to varenicline (n = 19), naltrexone (n = 15), or matched placebo (n = 19). In this 6-day practice quit trial, participants attempted to abstain from drinking and completed

SUBMITTER: Kady A 

PROVIDER: S-EPMC11217986 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature