Benzodiazepine use in relation to long-term dementia risk and imaging markers of neurodegeneration: a population-based study.

ABSTRACT:

Background

Benzodiazepine use is common, particularly in older adults. Benzodiazepines have well-established acute adverse effects on cognition, but long-term effects on neurodegeneration and dementia risk remain uncertain.

Methods

We included 5443 cognitively healthy (MMSE ≥ 26) participants from the population-based Rotterdam Study (57.4% women, mean age 70.6 years). Benzodiazepine use from 1991 until baseline (2005-2008) was derived from pharmacy dispensing records, from which we determined drug type and cumulative dose. Benzodiazepine use was defined as prescription of anxiolytics (ATC-code: N05BA) or sedative-hypnotics (ATC-code: N05CD) between inception of pharmacy records and study baseline. Cumulative dose was calculated as the sum of the defined daily doses for all

SUBMITTER: Hofe IV 

PROVIDER: S-EPMC11218055 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature