Role of plasma fatty acid in age-related macular degeneration: insights from a mendelian randomization analysis.

ABSTRACT:

Background

An imbalance in lipid metabolism has been linked to the development of AMD, but the causal relationship between AMD and plasma fatty acids (FAs) remains controversial. Using a two-sample Mendelian randomization (MR) approach, we sought to evaluate the impact of specific FA plasma levels on the risk of different AMD subtypes.

Methods

We analysed genome-wide association data of circulating FAs from 115,006 European-descended individuals in the UK Biobank. These data were used in a two-sample MR framework to assess the potential role of circulating FAs in developing wet and dry AMD. Sensitivity analyses were conducted to ensure the robustness of our findings. Additional multivariable and locus-specific MR analyses were conducted to evaluate direct effects of FA on AM

SUBMITTER: Han G 

PROVIDER: S-EPMC11218068 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature