Microbial signatures and continuum in endometrial cancer and benign patients.

ABSTRACT:

Background

Endometrial cancer is a multifactorial disease with inflammatory, metabolic and potentially microbial cues involved in disease pathogenesis. The endometrial cancer microbiome has been poorly characterised so far and studies have often overestimated bacterial biomass due to lack of integration of appropriate contamination controls. There is also a scarcity of evidence on the functionality of microbial microenvironments in endometrial cancer. This work addresses that knowledge gap by interrogating the genuine, contamination-free microbial signatures in the female genital tract and rectum of women with endometrial cancer and the mechanistic role of microbiome on carcinogenic processes.

Results

Here we sampled different regions of the reproductive tract (vagina, cervi

SUBMITTER: Semertzidou A 

PROVIDER: S-EPMC11218081 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature