Metagenomic and metabolomic analysis showing the adverse risk-benefit trade-off of the ketogenic diet.

ABSTRACT:

Background

Ketogenic diets are increasingly popular for addressing obesity, but their impacts on the gut microbiota and metabolome remain unclear. This paper aimed to investigate how a ketogenic diet affects intestinal microorganisms and metabolites in obesity.

Methods

Male mice were provided with one of the following dietary regimens: normal chow, high-fat diet, ketogenic diet, or high-fat diet converted to ketogenic diet. Body weight and fat mass were measured weekly using high-precision electronic balances and minispec body composition analyzers. Metagenomics and non-targeted metabolomics data were used to analyze differences in intestinal contents.

Results

Obese mice on the ketogenic diet exhibited notable improvements in weight and body fat. However, these were a

SUBMITTER: Qiu H 

PROVIDER: S-EPMC11218088 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature