Metabolic requirements of CD160 expressing memory-like NK cells in Gram-negative bacterial infection.

ABSTRACT:

Objective

Unique metabolic requirements accompany the development and functional fates of immune cells. How cellular metabolism is important in natural killer (NK) cells and their memory-like differentiation in bacterial infections remains elusive.

Methods

Here, we utilise our established NK cell memory assay to investigate the metabolic requirement for memory-like NK cell formation and function in response to the Gram-negative intracellular bacteria Burkholderia pseudomallei (BP), the causative agent of melioidosis.

Results

We demonstrate that CD160⁺ memory-like NK cells upon BP stimulation upregulate glucose and amino acid transporters in a cohort of recovered melioidosis patients which is maintained at least 3-month post-hospital admission. Using

SUBMITTER: Preechanukul A 

PROVIDER: S-EPMC11218174 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature