Senescent endothelial cells promote liver metastasis of uveal melanoma in single-cell resolution.

ABSTRACT:

Background

Uveal melanoma (UM), the most common adult intraocular tumor, is characterized by high malignancy and poor prognosis in advanced stages. Angiogenesis is critical for UM development, however, not only the role of vascular endothelial dysfunction in UM remains unknown, but also their analysis at the single-cell level has been lacking. A comprehensive analysis is essential to clarify the role of the endothelium in the development of UM.

Methods

By using single-cell RNA transcriptomics data of 11 cases of primary and liver metastasis UM, we analyzed the endothelial cell status. In addition, we analyzed and validated ECs in the in vitro model and collected clinical specimens. Subsequently, we explored the impact of endothelial dysfunction on UM cell migration and explo

SUBMITTER: Ma L 

PROVIDER: S-EPMC11218175 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature