Genomic characteristics and evolution of Multicentric Esophageal and gastric Cardiac Cancer.

ABSTRACT:

Background

Esophageal carcinoma (EC) and gastric cardiac adenocarcinoma (GCA) have high incidence rates in the Chaoshan region of South China. Multifocal esophageal and cardiac cancer (MECC) is commonly observed in this region in clinical practice. However, the genomic characteristics of MECC remains unclear.

Materials and methods

In this study, a total of 2123 clinical samples of EC and GCA were analyzed to determine the frequency of multifocal tumors, as well as their occurrence sites and pathological types. Cox proportional hazards regression was used to model the relationship between age, sex, and tumor state concerning survival in our analysis of the cohort of 541 patients with available follow-up data. We performed whole-genome sequencing on 20 tumor foci and 10 normal

SUBMITTER: Liu X 

PROVIDER: S-EPMC11218177 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature