Association between HIV and acquisition of rifamycin resistance with first-line TB treatment: a systematic review and meta-analysis.

ABSTRACT:

Background

Multi-drug or rifamycin-resistant tuberculosis (MDR/RR-TB) is an important public health concern, including in settings with high HIV prevalence. TB drug resistance can be directly transmitted or arise through resistance acquisition during first-line TB treatment. Limited evidence suggests that people living with HIV (PLHIV) might have an increased risk of acquired rifamycin-resistance (ARR).

Methods

To assess HIV as a risk factor for ARR during first-line TB treatment, a systematic review and meta-analysis was conducted. ARR was defined as rifamycin-susceptibility at treatment start with rifamycin-resistance diagnosed during or at the end of treatment, or at recurrence. PubMed/MEDLINE, CINAHL, Cochrane Library, and Google Scholar databases were searched from ince

SUBMITTER: Zinyakatira N 

PROVIDER: S-EPMC11218187 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature