Programmable magnetic robot (ProMagBot) for automated nucleic acid extraction at the point of need.

ABSTRACT: Upstream sample preparation remains the bottleneck for point-of-need nucleic acid testing due to its complexity and time-consuming nature. Sample preparation involves extracting, purifying, and concentrating nucleic acids from various matrices. These processes are critical for ensuring the accuracy and sensitivity of downstream nucleic acid amplification and detection. However, current sample preparation methods are often laboratory-based, requiring specialized equipment, trained personnel, and several hours of processing time. As a result, sample preparation often limits the speed, portability, and cost-effectiveness of point-of-need nucleic acid testing. A universal, field-deployable sample preparation device is highly desirable for this critical need and unmet challenge. Here we reporte

SUBMITTER: Politza AJ 

PROVIDER: S-EPMC11218199 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature