Alterations of the bile microbiome is associated with progression-free survival in pancreatic ductal adenocarcinoma patients.

ABSTRACT:

Background

Patients with pancreatic ductal adenocarcinoma (PDAC) display an altered oral, gastrointestinal, and intra-pancreatic microbiome compared to healthy individuals. However, knowledge regarding the bile microbiome and its potential impact on progression-free survival in PDACs remains limited.

Methods

Patients with PDAC (n = 45), including 20 matched pairs before and after surgery, and benign controls (n = 16) were included prospectively. The characteristics of the microbiomes of the total 81 bile were revealed by 16  S-rRNA gene sequencing. PDAC patients were divided into distinct groups based on tumor marker levels, disease staging, before and after surgery, as well as progression free survival (PFS) for further analysis. Disease diagnostic model was formulated util

SUBMITTER: Jiang H 

PROVIDER: S-EPMC11218221 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature