The survival prediction of advanced colorectal cancer received neoadjuvant therapy-a study of SEER database.

ABSTRACT:

Purpose

The aim of study was to screen factors associated with the overall survival of colorectal cancer patients with lymph nodes metastasis who received neoadjuvant therapy and construct a nomogram model.

Methods

All enrolled subjects of the SEER database were randomly assigned to the training and testing group in a ratio of 3:2. The patients of Tangdu Hospital were seemed as validation group. Univariate cox regression analysis, lasso regression and random forest survival were used to screen variables related to the survival of advanced CRC patients received neoadjuvant therapy in the training group. Area under curves were adopted to evaluate the 1,3,5-year prediction value of the optimal model in three cohorts. Calibration curves were drawn to observe the prediction accur

SUBMITTER: Han Z 

PROVIDER: S-EPMC11218294 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature