FENko-Kae01 is a flagellum-specific jumbo phage infecting Klebsiella aerogenes.

ABSTRACT:

Background

Klebsiella aerogenes is an opportunistic pathogen that causes a wide variety of infections. Due to the rising problem of antibiotic resistance, novel antibiotics and strategies to combat bacterial infections are needed. Host-specific bacteriophages are natural enemies of bacteria and can be used in phage therapy as an alternative form of treatment against bacterial infections. Jumbo phages are defined as phages with genomes larger than 200 kb. Relatively few studies have been done on jumbo phages compared to smaller phages.

Results

A novel phage, fENko-Kae01, was isolated from a commercial phage cocktail. Genomic analysis revealed that fENko-Kae01 is a lytic jumbo phage with a 360 kb genome encoding 578 predicted genes. No highly similar phage genomes were identif

SUBMITTER: Ranta K 

PROVIDER: S-EPMC11218385 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature