Enhancement of protein production in Aspergillus niger by engineering the antioxidant defense metabolism.

ABSTRACT:

Background

Research on protein production holds significant importance in the advancement of food technology, agriculture, pharmaceuticals, and bioenergy. Aspergillus niger stands out as an ideal microbial cell factory for the production of food-grade proteins, owing to its robust protein secretion capacity and excellent safety profile. However, the extensive oxidative folding of proteins within the endoplasmic reticulum (ER) triggers ER stress, consequently leading to protein misfolding reactions. This stressful phenomenon results in the accelerated generation of reactive oxygen species (ROS), thereby inducing oxidative stress. The accumulation of ROS can adversely affect intracellular DNA, proteins, and lipids.

Result

In this study, we enhanced the detoxification of ROS in

SUBMITTER: Chen X 

PROVIDER: S-EPMC11218396 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature