Mycobacterium tuberculosis is less likely to acquire pathogenic mutations during latent infection than during active disease.

ABSTRACT: Most people infected with Mycobacterium tuberculosis (Mtb) are believed to be in a state of latent tuberculosis (TB) infection (LTBI). Although LTBI is asymptomatic and not infectious, there is a risk of developing active disease even decades after infection. Here, to characterize mutations acquired during LTBI, we collected and analyzed Mtb genomes from seven Japanese patient pairs, each pair consisting of two active TB patients whose starting dates of developing active disease were >3 years apart; one had a high suspicion of LTBI before developing active disease, whereas the other did not. Thereafter, we compared these genomes with those of longitudinal sample pairs within a host of chronic active TB infections combined with public data. The bacterial populations in

SUBMITTER: Osugi A 

PROVIDER: S-EPMC11218478 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature