Electroanatomical adaptations in the guinea pig heart from neonatal to adulthood.

ABSTRACT:

Aims

Electroanatomical adaptations during the neonatal to adult phase have not been comprehensively studied in preclinical animal models. To explore the impact of age as a biological variable on cardiac electrophysiology, we employed neonatal and adult guinea pigs, which are a recognized animal model for developmental research.

Methods and results

Electrocardiogram recordings were collected in vivo from anaesthetized animals. A Langendorff-perfusion system was employed for the optical assessment of action potentials and calcium transients. Optical data sets were analysed using Kairosight 3.0 software. The allometric relationship between heart weight and body weight diminishes with age, it is strongest at the neonatal stage (R2 = 0.84) and abolished in older adults (R2 = 1E-0

SUBMITTER: Haq KT 

PROVIDER: S-EPMC11218563 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature