Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction.

ABSTRACT:

Aims

In patients with heart failure (HF), concomitant sinus node dysfunction (SND) is an important predictor of mortality, yet its molecular underpinnings are poorly understood. Using proteomics, this study aimed to dissect the protein and phosphorylation remodelling within the sinus node in an animal model of HF with concurrent SND.

Methods and results

We acquired deep sinus node proteomes and phosphoproteomes in mice with heart failure and SND and report extensive remodelling. Intersecting the measured (phospho)proteome changes with human genomics pharmacovigilance data, highlighted downregulated proteins involved in electrical activity such as the pacemaker ion channel, Hcn4. We confirmed the importance of ion channel downregulation for sinus node physiology using compute

SUBMITTER: Kahnert K 

PROVIDER: S-EPMC11218694 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature