Prolonged Cadmium Exposure and Osteoclastogenesis: A Mechanistic Mouse and in Vitro Study.

ABSTRACT:

Background

Cadmium (Cd) is a highly toxic and widespread environmental oxidative stressor that causes a myriad of health problems, including osteoporosis and bone damage. Although nuclear factor erythroid 2-related factor 2 (NRF2) and its Cap 'n' Collar and basic region Leucine Zipper (CNC-bZIP) family member nuclear factor erythroid 2-related factor 1 (NRF1) coordinate various stress responses by regulating the transcription of a variety of antioxidant and cytoprotective genes, they play distinct roles in bone metabolism and remodeling. However, the precise roles of both transcription factors in bone loss induced by prolonged Cd exposure remain unclear.

Objectives

We aimed to understand the molecular mechanisms underlying Cd-induced bone loss, focusing mainly on the roles o

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11218709 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature