The N-terminal domains of NLR immune receptors exhibit structural and functional similarities across divergent plant lineages.

ABSTRACT: Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are a prominent class of intracellular immune receptors in plants. However, our understanding of plant NLR structure and function is limited to the evolutionarily young flowering plant clade. Here, we describe an extended spectrum of NLR diversity across divergent plant lineages and demonstrate the structural and functional similarities of N-terminal domains that trigger immune responses. We show that the broadly distributed coiled-coil (CC) and toll/interleukin-1 receptor (TIR) domain families of nonflowering plants retain immune-related functions through translineage activation of cell death in the angiosperm Nicotiana benthamiana. We further examined a CC subfamily specific to nonflowering lineages and uncovered an essenti

SUBMITTER: Chia KS 

PROVIDER: S-EPMC11218826 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature