Immune cells and checkpoints in pancreatic adenocarcinoma: Association with clinical and pathological characteristics.

ABSTRACT:

Introduction

Pancreatic adenocarcinoma is an extremely aggressive neoplasm, with many challenges to be overcome in order to achieve a truly effective treatment. It is characterized by a mostly immunosuppressed environment, with dysfunctional immune cells and active immunoinhibitory pathways that favor tumor evasion and progression. Thus, the study and understanding of the tumor microenvironment and the various cells subtypes and their functional capacities are essential to achieve more effective treatments, especially with the use of new immunotherapeutics.

Methods

Seventy cases of pancreatic adenocarcinoma divided into two groups 43 with resectable disease and 27 with unresectable disease were analyzed using immunohistochemical methods regarding the expression of programmed

SUBMITTER: Cysneiros MAPC 

PROVIDER: S-EPMC11218951 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature