Hippocampus and striatum show distinct contributions to longitudinal changes in value-based learning in middle childhood.

ABSTRACT: The hippocampal-dependent memory system and striatal-dependent memory system modulate reinforcement learning depending on feedback timing in adults, but their contributions during development remain unclear. In a 2-year longitudinal study, 6-to-7-year-old children performed a reinforcement learning task in which they received feedback immediately or with a short delay following their response. Children's learning was found to be sensitive to feedback timing modulations in their reaction time and inverse temperature parameter, which quantifies value-guided decision-making. They showed longitudinal improvements towards more optimal value-based learning, and their hippocampal volume showed protracted maturation. Better delayed model-derived learning covaried with larger hippocampal volume lon

SUBMITTER: Falck J 

PROVIDER: S-EPMC11219037 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature