Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome.

ABSTRACT: The enhancement of associative synaptic plasticity often results in impaired rather than enhanced learning. Previously, we proposed that such learning impairments can result from saturation of the plasticity mechanism (Nguyen-Vu et al., 2017), or, more generally, from a history-dependent change in the threshold for plasticity. This hypothesis was based on experimental results from mice lacking two class I major histocompatibility molecules, MHCI H2-K^b and H2-D^b (MHCI K^bD^b-/-), which have enhanced associative long-term depression at the parallel fiber-Purkinje cell synapses in the cerebellum (PF-Purkinje cell LTD). Here, we extend this work by testing predictions of the threshold metaplasticity hypothesis in a second mouse line with enhanced PF-Pu

SUBMITTER: Shakhawat AMD 

PROVIDER: S-EPMC11219043 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature