Immunotherapy-relevance of a candidate prognostic score for Acute Myeloid Leukemia.

ABSTRACT:

Background

Acute Myeloid Leukemia (AML) exhibits a wide array of phenotypic manifestations, progression patterns, and heterogeneous responses to immunotherapies, suggesting involvement of complex immunobiological mechanisms. This investigation aimed to develop an integrated prognostic model for AML by incorporating cancer driver genes, along with clinical and phenotypic characteristics of the disease, and to assess its implications for immunotherapy responsiveness.

Methods

Critical oncogenic driver genes linked to survival were identified by screening primary effector and corresponding gene pairs using data from The Cancer Genome Atlas (TCGA), through univariate Cox proportional hazard regression analysis. This was independently verified using dataset GSE37642. Primary effec

SUBMITTER: Pan Y 

PROVIDER: S-EPMC11219318 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature