Antihypertensive drug targets and breast cancer risk: a two-sample Mendelian randomization study.

ABSTRACT: Findings on the correlation between the use of antihypertensive medication and the risk of breast cancer (BC) have been inconsistent. We performed a two-sample Mendelian randomization (MR) using instrumental variables to proxy changes in gene expressions of antihypertensive medication targets to interrogate this. Genetic instruments for expression of antihypertensive drug target genes were identified with expression quantitative trait loci in blood, which should be associated with systolic blood pressure to proxy for the effect of antihypertensive drug. The association between genetic variants and BC risk were obtained from genome-wide association study summary statistics. The summary-based MR was employed to estimate the drug effects on BC risk. We further performed sensitivity analyses t

SUBMITTER: Zheng G 

PROVIDER: S-EPMC11219410 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature