Causal relations between ischemic stroke and epilepsy: A bidirectional Mendelian randomization study.

ABSTRACT:

Background

Although previous studies have reported a bidirectional relationship between ischemic stroke (IS) and epilepsy, the existence of a causal nexus and its directionality remains a topic of controversy.

Methods

The single nucleotide polymorphisms (SNPs) associated with IS were extracted from the Genome-Wide Association Study (GWAS) database. Pooled genetic data encompassing all epilepsy cases, as well as generalized and focal epilepsy subtypes, were acquired from the International League Against Epilepsy's GWAS study. In this study, the primary analysis approach utilized the inverse variance weighting (IVW) method as the main analytical technique. To enhance the robustness of the findings against potential pleiotropy, additional sensitivity analyses were conducted.

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC11219486 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature