Dihydroartemisinin inhibits HNSCC invasion and migration by controlling miR-195-5p expression.

ABSTRACT:

Objectives

Dihydroartemisinin (DHA), an artemisinin derivative extracted from the traditional Chinese medicinal herb Artemisia annua, has the potential to suppress head and neck squamous cell carcinoma (HNSCC) progression. However, the mechanisms underlying these effects remain unclear. Therefore, we aimed to examine the mechanisms underlying the effects of DHA on tumor invasion and migration.

Methods

Human HNSCC cell lines CAL-27 and FaDu were exposed to varying DHA concentrations (0, 5, 20, and 80 μM) for 24 h. Cell proliferation, invasion, and migration were assessed using CCK8, transwell, and wound-healing assays, respectively. Quantitative real-time PCR, western blotting, and immunofluorescence were used to assess the expression levels of the target genes and pro

SUBMITTER: Wu X 

PROVIDER: S-EPMC11219504 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature