Causal association between immune cells and lung cancer risk: a two-sample bidirectional Mendelian randomization analysis.

ABSTRACT:

Background

Previous studies have highlighted the crucial role of immune cells in lung cancer development; however, the direct link between immunophenotypes and lung cancer remains underexplored.

Methods

We applied two-sample Mendelian randomization (MR) analysis, using genetic variants as instruments to determine the causal influence of exposures on outcomes. This method, unlike traditional randomized controlled trials (RCTs), leverages genetic variants inherited randomly at conception, thus reducing confounding and preventing reverse causation. Our analysis involved three genome-wide association studies to assess the causal impact of 731 immune cell signatures on lung cancer using genetic instrumental variables (IVs). We initially used the standard inverse variance weighted

SUBMITTER: Xu S 

PROVIDER: S-EPMC11219561 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature