Monocyte infiltration is an independent positive prognostic biomarker in vulvar squamous cell carcinoma.

ABSTRACT:

Background

Vulvar squamous cell carcinoma (VSCC) arises after an HPV infection or the mutation of p53 or other driver genes and is treated by mutilating surgery and/or (chemo) radiation, with limited success and high morbidity. In-depth information on the immunological make up of VSCC is pivotal to assess whether immunotherapy may form an alternative treatment.

Methods

A total of 104 patient samples, comprising healthy vulva (n = 27) and VSCC (n = 77), were analyzed. Multispectral immunofluorescence (15 markers) was used to study both the myeloid and lymphoid immune cell composition, and this was linked to differences in transcriptomics (NanoString nCounter, 1258 genes) and in survival (Kaplan-Meier analyses).

Results

Healthy vulva and VSCC are both well infiltrated b

SUBMITTER: Abdulrahman Z 

PROVIDER: S-EPMC11219697 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature