Comprehensive survey of conserved RNA secondary structures in full-genome alignment of Hepatitis C virus.

ABSTRACT: Hepatitis C virus (HCV) is a plus-stranded RNA virus that often chronically infects liver hepatocytes and causes liver cirrhosis and cancer. These viruses replicate their genomes employing error-prone replicases. Thereby, they routinely generate a large 'cloud' of RNA genomes (quasispecies) which-by trial and error-comprehensively explore the sequence space available for functional RNA genomes that maintain the ability for efficient replication and immune escape. In this context, it is important to identify which RNA secondary structures in the sequence space of the HCV genome are conserved, likely due to functional requirements. Here, we provide the first genome-wide multiple sequence alignment (MSA) with the prediction of RNA secondary structures throughout all representative full-length

SUBMITTER: Triebel S 

PROVIDER: S-EPMC11219754 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature