Temporal sex specific brain gene expression pattern during early rat embryonic development.

ABSTRACT: Background: The classical concept of brain sex differentiation suggests that steroid hormones released from the gonads program male and female brains differently. However, several studies indicate that steroid hormones are not the only determinant of brain sex differentiation and that genetic differences could also be involved. Methods: In this study, we have performed RNA sequencing of rat brains at embryonic days 12 (E12), E13, and E14. The aim was to identify differentially expressed genes between male and female rat brains during early development. Results: Analysis of genes expressed with the highest sex differences showed that Xist was highly expressed in females having XX genotype with an increasing expression over time. Analysis of genes expressed with t

SUBMITTER: Paylar B 

PROVIDER: S-EPMC11219815 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature