Identification of a novel lactylation-related gene signature predicts the prognosis of multiple myeloma and experiment verification.

ABSTRACT: Multiple myeloma (MM) is an incurable hematological malignancy with poor survival. Accumulating evidence reveals that lactylation modification plays a vital role in tumorigenesis. However, research on lactylation-related genes (LRGs) in predicting the prognosis of MM remains limited. Differentially expressed LRGs (DELRGs) between MM and normal samples were investigated from the Gene Expression Omnibus database. Univariate Cox regression and LASSO Cox regression analysis were applied to construct gene signature associated with overall survival. The signature was validated in two external datasets. A nomogram was further constructed and evaluated. Additionally, Enrichment analysis, immune analysis, and drug chemosensitivity analysis between the two groups were investigated. qPCR and immunofl

SUBMITTER: Sun C 

PROVIDER: S-EPMC11219856 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature