The significance of lipid metabolism reprogramming of tumor-associated macrophages in hepatocellular carcinoma.

ABSTRACT: In the intricate landscape of the tumor microenvironment, tumor-associated macrophages (TAMs) emerge as a ubiquitous cellular component that profoundly affects the oncogenic process. The microenvironment of hepatocellular carcinoma (HCC) is characterized by a pronounced infiltration of TAMs, underscoring their pivotal role in modulating the trajectory of the disease. Amidst the evolving therapeutic paradigms for HCC, the strategic reprogramming of metabolic pathways presents a promising avenue for intervention, garnering escalating interest within the scientific community. Previous investigations have predominantly focused on elucidating the mechanisms of metabolic reprogramming in cancer cells without paying sufficient attention to understanding how TAM metabolic reprogramming, particular

SUBMITTER: Xie Q 

PROVIDER: S-EPMC11220057 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature