Development of a top-down MS assay for specific identification of human periostin isoforms.

ABSTRACT: Periostin is a matricellular protein encoded by the POSTN gene that is alternatively spliced to produce ten different periostin isoforms with molecular weights ranging from 78 to 91 kDa. It is known to promote fibrillogenesis, organize the extracellular matrix, and bind integrin-receptors to induce cell signaling. As well as being a key component of the wound healing process, it is also known to participate in the pathogenesis of different diseases including atopic dermatitis, asthma, and cancer. In both health and disease, the functions of the different periostin isoforms are largely unknown. The ability to precisely determine the isoform profile of a given human sample is fundamental for characterizing their functional significance. Identification of periostin isoforms is most often carr

SUBMITTER: Rusbjerg-Weberskov CE 

PROVIDER: S-EPMC11220192 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature