Investigating the causal association between gut microbiota and type 2 diabetes: a meta-analysis and Mendelian randomization.

ABSTRACT:

Background

Studies have shown that gut dysbiosis contributes to the pathophysiology of type 2 diabetes mellitus (T2DM). Identifying specific gut microbiota dysbiosis may provide insight into the pathogenesis of T2DM.

Purpose

This study investigated the causal relationship between gut microbiota and T2DM using meta-analysis and Mendelian randomization (MR).

Methods

In the first part, we searched for literature on gut microbiota and T2DM, and conducted a meta-analysis. We observed differences in glycosylated hemoglobin and fasting blood glucose levels in both groups. Second, we obtained GWAS data from genome-wide association study database 19 (GWAS). We used two-sample MR analysis to verify the forward and reverse causal associations between gut microbiota and T2DM. Add

SUBMITTER: Liu T 

PROVIDER: S-EPMC11220316 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature