Evaluating the associations between intelligence quotient and multi-tissue proteome from the brain, CSF and plasma.

ABSTRACT: Intelligence quotient is a vital index to evaluate the ability of an individual to think rationally, learn from experience and deal with the environment effectively. However, limited efforts have been paid to explore the potential associations of intelligence quotient traits with the tissue proteins from the brain, CSF and plasma. The information of protein quantitative trait loci was collected from a recently released genome-wide association study conducted on quantification data of proteins from the tissues including the brain, CSF and plasma. Using the individual-level genotypic data from the UK Biobank cohort, we calculated the polygenic risk scores for each protein based on the protein quantitative trait locus data sets above. Then, Pearson correlation analysis was applied to evaluate

SUBMITTER: Shi S 

PROVIDER: S-EPMC11220507 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature