Self-reported neurocognitive complaints in the Swiss HIV Cohort Study: a viral genome-wide association study.

ABSTRACT: People with HIV may report neurocognitive complaints, with or without associated neurocognitive impairment, varying between individuals and populations. While the HIV genome could play a major role, large systematic viral genome-wide screens to date are lacking. The Swiss HIV Cohort Study biannually enquires neurocognitive complaints. We quantified broad-sense heritability estimates using partial 'pol' sequences from the Swiss HIV Cohort Study resistance database and performed a viral near full-length genome-wide association study for the longitudinal area under the curve of neurocognitive complaints. We performed all analysis (i) restricted to HIV Subtype B and (ii) including all HIV subtypes. From 8547 people with HIV with neurocognitive complaints, we obtained 6966 partial 'pol' sequenc

SUBMITTER: Zeeb M 

PROVIDER: S-EPMC11220509 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature