Extended-Infusion β-Lactam Therapy, Mortality, and Subsequent Antibiotic Resistance Among Hospitalized Adults With Gram-Negative Bloodstream Infections.

ABSTRACT:

Importance

Current evidence is conflicting for associations of extended-infusion β-lactam (EI-BL) therapy with clinical outcomes.

Objective

To investigate the association of EI-BL therapy with survival, adverse events, and emergence of antibiotic resistance in adults with gram-negative bloodstream infections (GN-BSI).

Design, setting, and participants

This cohort study of consecutive adults with GN-BSI admitted to 24 United States hospitals between January 1, 2019, and December 31, 2019, receiving EI-BL were compared with adults with GN-BSI receiving the same agents as intermittent infusion β-lactam (II-BL; ≤1-hour infusions). Statistical analysis was performed from January to October 2023.

Exposures

EI-BL (ie, ≥3-hour infusion).

Main outcomes and measures</

SUBMITTER: Karaba SM 

PROVIDER: S-EPMC11220563 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature